Modern lifestyle has increased the risk factors for the occurrence of cardiovascular diseases and liver diseases.
- Cardiovascular diseases are the leading cause of death worldwide. In Greece more than 360 people per 100,000 die every year because of them. Statins are one of the most well-established treatments for the prevention and treatment of atherosclerotic cardiovascular diseases. However, their use has been associated with certain adverse events, such as myopathy and risk of liver damage.
- Effective liver function is essential for the proper functioning of the gastrointestinal tract but also for the overall health condition. Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common chronic liver disease and it is related to an increased risk of developing atherosclerotic cardiovascular disease, independently of the presence of diabetes mellitus, hypertension and obesity.
Libytec Pharmaceuticals has developed Q10Stat, an innovative combination that contains CoQ10, selenium, choline, artichoke and thistle extracts, and C, Β1, Β6 and Β12 vitamins.
CoQ10 plays an indispensable role in intracellular energy production, which is its primary function. Statins, apart from reducing cholesterol synthesis, are also reducing the synthesis of other substances, like CoQ10 and selenium proteins.
Independently of this reduction, the concentrations of CoQ10 in the tissues are also decreasing with ageing, and dietary supplementation is usually not enough in abnormal conditions.
In clinical practice, adding CoQ10 in statin treatment reduces effectively muscle symptoms, while its addition to the conventional treatment of patients with chronic heart failure:
- improves the symptoms;
- reduces significantly the main adverse cardiovascular events.
Choline is another ingredient of Q10Stat, which is an essential molecule for the synthesis of certain neurotransmitters, cell membranes and lipoproteins. The liver is the main organ responsible for its metabolism.
Choline contributes to:
- normal metabolism of homocysteine;
- normal metabolism of lipids;
- maintaining normal liver function;
Choline deficiency may:
- cause muscle damage and abnormal fat deposition in the liver;
- lead to NAFLD.
The synergistic actions of Q10stat are further enhanced by selenium, artichoke and thistle extracts that protect the liver and have a beneficial effect on non-alcoholic fatty liver disease, as well as C, Β1, Β6 & Β12 vitamins, which enhance the protection against atherosclerosis and contribute to the normal metabolism of homocysteine.
The interdependence between CoQ10 and selenium is important. Selenium deficiency can prevent cells from achieving optimal CoQ10 concentrations, while adequate concentrations of CoQ10 should be available for cells to benefit from the optimal function of selenium.
Artichoke extracts affect lipid metabolism, reducing the endogenous production of cholesterol and triglycerides, while enhancing their excretion or redistribution. Furthermore, they promote bile production as they increase the amount of bile acids and cholesterol excreted with the bile.
The active ingredients of thistle extracts can also have beneficial effects on non-alcoholic fatty liver disease and are able to neutralise the hepatotoxic effects of many substances (ethanol, paracetamol, mushroom poisoning) because they act:
- as antioxidants, regulating intracellular glutathione content;
- as permeability regulators that prevent hepatotoxic agents from entering hepatocytes;
- as promoters of liver regeneration;
- as inhibitors of the transformation of hepatocytes into myofibroblasts.
Vitamin C is one of the most potent antioxidants and a scavenger of free radicals in biological systems. Diseases such as cardiovascular disorders are associated with inadequate concentrations. Therefore, the optimal intake of vitamin C can help in the prevention of atherosclerosis and its clinical consequences.
Vitamin Β1 contributes to the normal functioning of the heart. Β6 and Β12 vitamins contribute both to the normal metabolism of homocysteine and in reducing fatigue and tiredness.
Briefly, Q10Stat is a unique product with double protective action that can have positive effects on:
- Atherosclerosis
- Ischaemic heart disease
- Chronic heart failure
- Hypertrophic cardiomyopathy
- Hypertension
- Statin-induced cardiomyopathy
- Non-alcoholic fatty liver disease
Q10Stat administration can:
- Improve cardiac energy balance
- Reduce symptoms in patients with heart failure
- Reduce major adverse cardiovascular events
- Treat and prevent statin-induced muscular symptoms
- Have hepatoprotective action
- Help in hepatic enzyme regulation
- Be co-administered with traditional treatments
Q10Stat administration is recommended for:
- people who are taking statins;
- people who are suffering from cardiovascular diseases;
- its hepatoprotective action.
